Dr. SIDDHARTH SANE

Dr.Roopa Naik, DR. PRIYANKA KANEKAR

Abstract

Glaucomatous eyes with previously failed filtration surgery, young patients, previous inflammation, neovascularisation, previous intraocular surgery, trauma are high risk cases for failure of filtration surgeries. Adjunctive use of antimetabolites has been shown to increase success rate in high risk Glaucoma filtration surgery. Various complications by postoperative use of 5-FU prompted the study to investigate the intraoperative use of 5-FU in high risk cases of Glaucoma.

A prospective, comparative study of single, intraoperative use of 5-FU in 40 patients of high risk for Glaucoma filtration surgery. Results : None of the patients developed corneal epitheliopathy, hypotony, maculopathy or endophthalmitis. Minor non sight threatening complications like shallow AC (responded to pressure patching) and hyphaema (underwent spontaneous resolution) were noted in 9 and 2 patients respectively.

Conclusion: Intraoperative 5-FU is safer and more effective as compared to postoperative injection.