Dr. Sneha Brijkishor Gupta

Dr. ROHIT SHETTY, Dr.Gairik Kundu

Abstract

Purpose:To use computational approach to determine region of biomechanical degeneration in keratoconus(KC)&use it for planning customized corneal crosslinking(CXL).

Methods:Customized CXL was done on10KCeyes.Maximum energy used was7.5J/cm2, intensity10mW/cm2&maximumUV time13.5mins.Computation approach using inverse finite element&artificial intelligence optimization was used to estimate region of mechanical degeneration.Customized profile was family of concentric circles positioned such that outermost circle did not exceed central 8mm zone.

Results:K1&K2decreased by-1.05D[-1.8,-0.3]&-1.17D[-2.27,-0.07].Kmax decreased by-1.91D[-3.15,-0.66],defocusby1.99µm[0.55,3.44],spherical aberration by0.35µm[0.09,0.62] ,RMSlower& higher order aberrations by14%.

Conclusions:Safety of customizedCXLusing computational approach was determined.Change in corneal parameters were superior to results of published outcomes.Further study with larger sample size is required to validate findings of this study