Dr.ANANYA GOSWAMI

Dr. J. S. TITIYAL, DR.MANPREET KAUR, Dr. NAMRATA SHARMA

Abstract

Purpose: To compare effect of topical Chloroquine (CQ) & cyclosporine-A (CsA) as an adjunct to standard therapy in maintaining post-LASIK ocular surface stability

Methods: Randomized controlled trial of cases undergoing LASIK- control group(n=52) received standard therapy, CsA group(n=49)- standard +CsA, CQ group(n=43)- standard +CQ. Outcome measures were OSDI score, tear-film MMP-9 levels, tear osmolarity, TBUT, Schirmers (ST) & visual acuity (VA). Follow up done at 1, 3 & 6 months.

Results: At 6 months, OSDI score, MMP-9, tear osmolarity, TBUT & ST were significantly better in CQ and CsA groups compared to control (p<0.001). VA was comparable in all. CsA group had better TBUT (p<0.001) and tear osmolarity (p=0.007) values as compared with CQ. OSDI score, ST and MMP-9 were comparable between CsA & CQ groups. Conclusion: Both CQ & CsA are useful adjuncts to standard therapy in maintaining ocular surface stability after LASIK. CsA is superior to CQ in terms of tear osmolarity & TBUT.

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