Dr. Sneha Brijkishor Gupta

Dr. ROHIT SHETTY, Dr.Pooja Khamar

Abstract

PURPOSE: To Study changes and binding of collagen fibrils pre and post crosslinking(CXL) eyes using polarization sensitive (PS) – OCT.

METHODS: 50 normal, 25 eyes of KC, pre and post-CXL were imaged with PS-OCT at 1,3,6 months. Scan of 11mm diameter were captured, Corneal fibril distribution images was generated using phase retardation, axis orientation enface maps. Eyes were imaged 3 times for repeatability.

RESULTS: Enface maps of KC eyes showed an abrupt change in preferential arrangement of collagen fibril structures. Binding of collagen fibrils appeared to be weak in KC eyes. This weak binding of collagen fibrils strengthened at 3 months post CXL and stabilized at 6 months with a relatively stronger binding as compared to preoperative arrangements.

CONCLUSION: Binding density of collagen fibrils was observed to improve and strengthen, postoperatively. Posterior corneal enface maps can be used to track changes in collagen fibrils aiding in analysing effect of CXL procedure.