DR. PRASANNA VENKATESH RAMESH

Dr.R. RAMESH

Abstract

Purpose: To Compare Bruch’s Membrane Opening-Minimum Rim Width (BMO-MRW), Retinal Nerve Fibre Layer (RNFL) and Ganglion Cell Layer (GCL) of normal, suspects, primary open angle and closed angle glaucoma patients.

Methods: In a case control, cross-sectional study, 160 eyes (40 normal, 40 suspects, 40 POAG, 40 PACG) were evaluated.

Results: Mean BMO area was 2.36 ± 0.60 mm2. The global BMO-MRW were as follows: 243.10 ± 57.27µm (normals)> 229.40 ± 46.62µm (suspects)> 209.38 ± 52.38µm (PACG)> 208.08 ± 57.74µm (POAG). Diagnostic precision of BMO MRW was analysed for small BMO area and large BMO area separately. In ROC analysis, diagnostic power to differentiate glaucoma suspects from healthy controls was highest for BMO-MRW (Area under curve, AUC = 0.56: sensitivity at 85%, specificity 82%) irrespective of BMO area.

Conclusion: BMO-MRW has the best diagnostic power to discriminate glaucoma suspects from normal controls. GCL has better power to discriminate glaucoma suspects from glaucoma.

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