DR. SANJAY BOSAK

DR. TANMAY SRIVASTAV, Dr. MAURYA R. P., Dr.Virendra Pratap Singh

Abstract

Aim: The aim of our study was to determine frequency of p53 gene mutation in various eyelid carcinomas.

Methods: It was cross sectional study in which random samples of patients with various types of eyelid tumors were collected. All cases of primary eyelid carcinoma who did not receive any chemotherapy or irradiation before were taken.Biopsy was taken from the tumor site including healthy margin for genetic analysis.

Results:Out of 20patients,10were of sebaceous gland carcinoma. The study demonstrated that the p53 gene was mutated in 45% of total eyelid carcinoma.We observed total 14mutations in 9patients out of 20 patients. Out of total 14mutations,8 were intronic variation, which was novel polymorphic variation. Six out of 14 mutations were exonic variation, which was disease causing mutation.

Conclusion: Among human cancers,eyelid carcinomas may be one of those showing most frequent mutation of p53gene.Identification of these mutations may lead to better understanding of disease.