DR. GAURAV SINGH

Dr. J.L. GOYAL, Dr.Raina Usha Kaul, Dr.PRATEEKSHA SHARMA

Abstract

PURPOSE:To compare the outcomes of autologous serum eyedrops(ASE)&artificial tears(ATs) in persistent corneal epithelial defects(PEDs) more than 2weeks duration.METHODS:Prospective comparative study wherein 32such eyes were randomly divided into 2equal groups.GroupA received ASE&groupB received ATs for minimum 4weeks.Patients were evaluated for change in BCVA,size of defect,depth of defect on AS-OCT,corneal sensations,improvement in subjective symptoms.Success was defined as complete epithelialization of the defect.Results:The success rate of groupA by the end of 4weeks was 81.25%&groupB 37.5%.The days required in complete healing were significantly lesser in groupA compared to groupB(p-value=0.015) with significant improvement in BCVA(p-value=0.029)&earlier resolution of subjective symptoms.Conclusion:Though the eventual outcome was comparable,ATs had a significantly longer&static course of recovery compared to ASE&thus ASE should be considered as an adjuvant in the treatment of PEDs.