Dr. MAURYA R. P.

Dr.Virendra Pratap Singh, Dr. MEGHNA ROY, Dr.RAVINA TODI

Abstract

Purpose:To study the clinico-pathological characteristics,treatment outcome of giant OSSN.Methods:Retrospective,observational study of 36patients treated for giant OSSN(involving ≥6limbal clock hours).Clinical pattern and response of surgical excision with AMT graft/IFNα2β were assessed.Results:Out of 102patients;36 eyes(36cases)had giant OSSN.Mean age was 65±12years.Mean duration of symptoms was 8.25months.Right eye was involved in 58.33%.Cornea was involved in 61.11% cases.58.33%patients had>12LImbal clock hours ,25.0% had 10 clock hours and rest16.67% patients had 8 clock hours involvement.Mean tumor hight was 3.10±1.08mm.In 22.22%cases OSSN was invasive type.Overall,complete regression after topical plus intralesional IFNα2β was seen in 52.78%cases during mean follow-up of 12.5±2.6months.Recurrence was seen in19.44%cases.Exenteration was done in 4 eye.Conclusion:IFNα2β is effective modality for giant OSSN,it reduces recurrence rate.Thus it should be considered as primary therapy.