DR. SNEHA JAIN

Dr. ASIM KUMAR GHOSH

Abstract

Purpose: To assess the association between baseline subfoveal choroidal thickness and short term response to intravitreal ranibizumab (IVR) therapy in center involving diabetic macular edema (CI-DME). Method: A prospective observational study of 40 eyes of 40 newly diagnosed CI-DME cases over 1 year. Anatomic response (central macular thickness [CMT] ≥50 µm) and functional response (best corrected visual acuity [BCVA] gain ≥1 line) post treatment with 3 monthly IVR were correlated with baseline subfoveal choroidal thickness (SFCT). Result: Baseline SFCT in anatomical responders (27 eyes) was greater than nonresponders (p<0.0001). Initial SFCT in functional responders (24 eyes) was greater compared to nonresponders (p<0.0001). Baseline SFCT showed strong positive correlation with significant change in CMT and BCVA after IVR . Conclusion: Baseline SFCT may help predict short-term IVR treatment outcomes in treatment-naive DME. Patients with greater baseline SFCT showed better results.