Dr.Parul Chawla Gupta

Dr.Jagat Ram

Abstract

Introduction: The aim of the study was to develop a prediction nomogram to assess the probability of infant being at risk for congenital rubella based on demographics and ophthalmological findings.

Methods: This was a cross-sectional sentinel surveillance study involving 1134 infants. The diagnosis of rubella was made using standard guidelines. Results: The average (median) age of the suspected CRS infants was 3 (IQR 1-6) months and the average (mean) age of their mothers was 25.8 ± 4.1 years. The final model showed that the odds of cataract, retinopathy, glaucoma, microcornea and age of infant at presentation are 3.1 (2.2-4.3), 4.9(2.3-10.4), 2.7(1.1-5.9), 2.3(1.1-4.7) and 1.1 (1-1.1). AUC of final model was 0.68 (95% C.I. Delong, 0.64 – 0.72). Nomogram along with a web version was developed.

Conclusion: The developed nomogram would have a wide community-based utilization and will help in prioritizing attention to high risk children thereby avoiding loss to follow up.

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