DR. ANUPRIYA CHAUBEY

Dr. SANDEEP SAXENA, Dr.SOMNATH DE, Dr. APJIT KAUR

Abstract

Aim: To study the mechanism of restoration of photoreceptor ellipsoid zone(EZ) after intravitreal bevacizumab (IVB) therapy, in diabetic macular edema(DME)Method: 44 consecutive patients aged 40-65 years having type 2 diabetes mellitus with DME were prospectively recruited for IVB comprising of 3 doses (1.25mg in 0.05ml) at monthly intervals.Visual acuity(logMAR VA) was recorded. SD-OCT was performed.Central sub-foveal thickness (CST) and grades of disruption of EZ were assessed.Clinical trials registry: CTRI/2019/03/018135.Results: Mean logMAR VA decreased after IVB regimen from 1.78±0.07 pre-intervention to 0.42±0.05 (p<0.001).CST reduced from 354.23±15.0µm pre-intervention to 233.18±7.88µm post intervention (p<0.001). Global EZ disruption reduced from 79.5% to 25% (1st dose) to 18.4% (2nd dose) to 11.4 % (post-intervention)(p<0.001)Conclusion:Anti-VEGF therapy causes restoration of ellipsoid zone with corresponding improvement in logMAR VA and decrease in CST in patients with DME[advanced_iframe src="https://view.officeapps.live.com/op/embed.aspx?src=https://aiosproceedings.s3.ap-southeast-1.amazonaws.com/2021/E-Poster/FP1468.pptx" width="100%" height="608"]