Dr. RITESH VERMA

Dr.Satvir Singh, Dr. JITENDER KUMAR, Dr.SAKSHI LOCHAB

Abstract

In recent years, intravitreal Bevacizumab (IVB) is being preferred as an initial treatment modality in Aggressive posterior retinopathy of prematurity.

24 eyes of 12 infants treated with IVB monotherapy(0.625mg) were analyzed regarding the initial response to IVB, the incidence of ROP reactivation, timing, location and stage of reactivation. The mean follow-up time was 30.2±1.4 weeks after IVB. Reactivation was identified in 8 eyes (33.3%). Reactivation in zone I was seen in only 2 eyes and zone II reactivation was present in 6 eyes. The mean post menstrual age (PMA) at the time of recurrence was 44.0±1.15 weeks (range 43-45). The mean time between initial treatment and treatment-requiring recurrence was 11.8±0.9 weeks. Multiple pregnancy, low birth weight, sepsis and necrotising enterocolitis were significantly associated with ROP reactivation. Recurrence of ROP should be carefully watched in a long-term follow-up after IVB monotherapy, particularly in the first 12 weeks after IVB.