Dr.kavitha cr

Dr. KAMALA SUBRAMANIAN, Dr. KAMALA SUBRAMANIAN, Dr.kavitha cr

Abstract

Purpose:To study the changes in corneal endothelium and central corneal thickness(CCT) in pseudoexfoliation syndrome(PXS) with or without glaucoma. Methods:total 112eyes, 60cases(30=PXS, 30=PXG) and 52 controls. All patients underwent non contact specular microscopy and ultrasound pachymetry to measure endothelial cell density(ECD), coefficient of variation in cell size(CV), percentage of hexagonality and CCT. Results:Mean ECD in PXS(2378.78cell/mm2) and PXG(2201.53cell/mm2) was lower than in the control group (2610.32cell/mm2)(P < 0.001). % of hexagonality in PXG group is 43.20%, was lower than in control group 51.82%(P<0.001). CCT in PXG (506.03mm) was lower than in controls (538.058mm) and as well PXS (531.63mm) (P<0.001). Conclusion:study confirms the existence of changes in endothelial cells in PXS with or with out glaucoma. Thinner corneas were found in PXG group and a possible independent role of CCT as a risk factor for the development of glaucoma in subjects with PXS.