Dr. MAURYA R. P.

Dr.MANISH PRAJAPAT, Dr.Virendra Pratap Singh, Dr. KIRTI VERMA

Abstract

PURPOSE:To detect oxidative stress and level of antioxidants in eyelid SGC patients receiving chemotherapy.METHODS:Atioxidant enzyme;Superoxide dismutase(SOD) and indicator of lipid peroxidation;Malondialdehyde(MDA) in the serum of 16cases of eyelid SGCreceiving Cis-platin,5FUcombination chemotherapy and16healthy controls by biochemical analysis.RESULTS:50%were advanced SGC and37.5%had nodal metastasis.Serum SOD level was lower in SGC cases(3.4275±0.37256nmol/ml) than in controls(5.6219±0.13580nmol/ml).MDA level was higher in cases than controls (5.5712±0.32779Vs 2.5531±0.08056,p<0.001).Oxidative stress (sMDA) was decreased after chemotherapy (5.5712±0.32779Vs 4.5146±0.23209,p<0.001).sSOD was increased after chemotherapy (p<0.001).Post chemo increase in sSOD and decrease in sMDA was more in metastatic and advanced stage SGC. CONCLUSION:Chemotherapy reduces oxidative stress.Serum MDA is a potential biomarker in SGC to assess oxidative stress and its impact on response to chemotherapy.