Dr.Kalishankar Das

DR. POIREITON ATHOKPAM, Dr.Kalishankar Das

Abstract

OBJECTIVE:To investigate if hyperglycemia in premature infants is an independent risk factor for ROP.

STUDY DESIGN:Premature infants [<1500g or <32 weeks GA] are enrolled in a cohort study. Bedside whole blood glucose concentration measured every 8 hours for first 7 days of life,any reading <50 or >150mg/dl ,serum sample were sent for confirmation.Hyperglycemia:>150mg/dl.ROP patients compared to non-ROP patients in a bivariate analysis.Variables significantly associated with ROP studied in a logistic regression model.

RESULTS:100 patients enrolled with GA <32 wks and birth weight <1500g ,48were hyperglycemic.30 cases (30%) had ROP( 19 in stage 1,10 in stage 2 &1 in stage 3).There were more cases of ROP in the hyperglycemia group compared to euglycemia group(45.83% vs 15.38%, p=0.007).Patients who developed ROP had significantly higher maximum and average blood glucose concentration when compared to non-ROP patients. CONCLUSION:Hyperglycemia is an independent risk factor of ROP.

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